Human multi-organ chips – a possible solution for animal free systemic ADMET testing
نویسندگان
چکیده
Animal free systemic toxicity and ADMe testing predictive of human exposure is currently the major challenge for science, regulatory bodies and the industry involved. On the one hand, modern test system engineering focuses mainly on single organ equivalents, rather than the systemic combination of organs. On the other hand, none of the currently available systems ensures long-term homeostasis of the respective tissues over months. this is primarily caused due to the lack of in vivo-like vasculature. On the basis of three design pillars – device, micro-architecture and culture process – we have designed a “multi-organ-chip” (MOC) platform technology. the MOC platform is I-2-218 Human multi-organ chips – a possible solution for animal free systemic ADMET testing G. Lindner 1, R. Horland 1, F. Sonntag 2, R. Lauster 3 and U. Marx 3 1tU Berlin, Department of Biotechnology, Berlin, Germany; 2Fraunhofer Institut, IWS Dresden, Dresden, Germany; 3technische Universität Berlin, Berlin, Germany
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